Asian Journal of Chemistry

A Green and Facile Synthesis of 2-Alkylsulfanyl-3H-quinazolin-4-one

BS Reddy, A Naidu, PK Dubey

Index: Reddy, B. Srinivasa; Naidu; Dubey Asian Journal of Chemistry, 2013 , vol. 25, # 5 p. 2644 - 2646

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Abstract

Abstract Reaction of 2-thioquinazolinone (1) with various alkylating agents like dimethyl sulphate, diethyl sulphate and benzyl chloride in the presence of K2CO3 as a mild base, by a simple physical grinding, microwave irradiation and PEG-600 under solvent-free conditions for 10-15 min at room temperature, followed by processing, gave respectively 2- methylsulfanyl-3H-quinazolin-4-one (2a, ie, R= CH3), 2-ethylsulfanyl-3H-quinazolin-4-one ...