A fast and simple method for the acylation of alcohols with acid chlorides promoted by metallic samarium

XS Jia, HL Wang, Q Huang, LL Kong…

Index: Jia, Xue-Shun; Wang, Hai-Long; Huang, Qing; Kong, Ling-Long; Zhang, Wei-He Journal of Chemical Research, 2006 , # 2 p. 135 - 138

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Citation Number: 2

Abstract

Carboxylic acid esters are well known for their applications in organic synthesis and their activity in the field of medicine. The commonly employed synthetic method is the acylation of alcohols with acid chlorides. In general, the acylations occur by the reaction in the presence of a base such as pyridine, TMEDA or triethylamine.1 Further, various catalysts have been developed for the acylation of alcohols with acid chlorides such as zinc chloride2 or alumina.3 However, ...