Interaction and reactivity of carcinogenic N-acetyl-N-(acyloxy)-2-aminofluorene with deoxyguanosine. An intramolecular approach

…, A Leterme, MF Lhomme, J Lhomme

Index: Defrancq, Eric; Pelloux, Nadia; Leterme, Anne; Lhomme, Marie-France; Lhomme, Jean Journal of Organic Chemistry, 1991 , vol. 56, # 16 p. 4817 - 4819

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Citation Number: 9

Abstract

Summary: Solvolysis of 3 in watertlcetone mixtures yields the" adduct" 4 (65% in water) with product and rate data consistent with the hypothesis that hydrophobic guanine-fluorene stacking, similar to that which occurs when the carcinogenic aminofluorene metabolite is ...

 Related Synthetic Route
((2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl 4-((N-(9H-fluoren-2-yl)acetamido)oxy)-4-oxobutanoate Structure

134756-81-3

((2R,3S,5R)-5-(...

~0%

Acetamide,N-9H-fluoren-2-yl-N-hydroxy- Structure

53-95-2

Acetamide,N-9H-...

4-(((2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)-4-oxobutanoic acid Structure

134756-83-5

4-(((2R,3S,5R)-...

2-acetamido-9H-fluoren-1-yl (((2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) succinate Structure

134737-00-1

2-acetamido-9H-...

Detail
((2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl 4-((N-(9H-fluoren-2-yl)acetamido)oxy)-4-oxobutanoate Structure

134756-81-3

((2R,3S,5R)-5-(...

~%

Acetamide,N-9H-fluoren-2-yl-N-hydroxy- Structure

53-95-2

Acetamide,N-9H-...

4-(((2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)-4-oxobutanoic acid Structure

134756-83-5

4-(((2R,3S,5R)-...

2-acetamido-9H-fluoren-3-yl (((2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) succinate Structure

134737-01-2

2-acetamido-9H-...

Detail

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