3-[[4-(4-Chlorophenyl) piperazin-1-yl] methyl]-1 H-pyrrolo [2, 3-b] pyridine: An Antagonist with High Affinity and Selectivity for the Human Dopamine D4 Receptor

…, R Marwood, S Patel, S Patel, CI Ragan…

Index: Kulagowski, Janusz J.; Broughton, Howard B.; Curtis, Neil R.; Mawer, Ian M.; Ridgill, Mark P.; Baker, Raymond; Emms, Frances; Freedman, Stephen B.; Marwood, Rosemarie; Patel, Shil; Patel, Smita; Ragan, C. Ian; Leeson, Paul D. Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 1941 - 1942

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Citation Number: 247

Abstract

of clozapine correlate more closely to its affinity for the D4 rather than D2 receptor, a property not shared by other antipsychotic agents. 13 Although controversial, 14 an association between the D4 receptor and schizophrenia was recently suggested by Seeman, 15 who found a 6-fold increase in D4 receptors in the caudate of schizophrenic patients relative to controls. These intriguing findings highlight the need for a selective ...