Abstract On the basis of our earlier studies, a series of N-{4-[4-(aryl) piperazin-1-yl]-phenyl}- amine derivatives containing terminal carbamoyl fragment with alkyl spacer of different lengths (15–20) were synthesized as ligands, for 5-hydroxytryptamine-1A (5-HT 1A) receptor. Molecular modeling studies were undertaken to explain the influence of spacer length on ligands affinity towards 5-HT 1A receptor. Compound 19 showed all the specific ...
