Tetrahedron letters

Synthesis of 1, 1, 1-trihalo-4-methoxy-4-[2-heteroaryl]-3-buten-2-ones, the corresponding butan-1, 3-dione and azole derivatives

…, S Brondani, N Zanatta, A Rosa, MAP Martins

Index: Flores, Alex F.C; Brondani, Sergio; Zanatta, Nilo; Rosa, Adriano; Martins, Marcos A.P Tetrahedron Letters, 2002 , vol. 43, # 48 p. 8701 - 8705

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Citation Number: 76

Abstract

The synthesis of 1, 1, 1-trihalo-4-methoxy-4-[2-thienyl]-3-buten-2-ones, 1, 1, 1-trihalo-4- methoxy-4-[2-furyl]-3-buten-2-ones and the respective trihalomethyl 1, 3-butanone derivatives by trihaloacylation of dimethoxy acetals derived from 2-acetylthiophene and 2- acetylfuran are reported. This is a convenient method to obtain fluorinated and chlorinated 1, 3-dielectrophiles from 2-acetylthiophene and 2-acetylfuran. The fluorinated 1, 3- ...