Fluorine-Containing Potential Anticancer Agents. II. 1a Syntheses of Some Trifluoromethylpurines and Trifluoromethylthiazolopyrimidines1b

H Nagano, S Inoue, AJ Saggiomo…

Index: Nagano,H. et al. J. Med. Chem., 1964 , vol. 7, p. 215 - 220

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Citation Number: 18

Abstract

Method A, applied to the 2-trifluoromethyl series gave the.~-acetamido-6-chloro-4- alkylamino-2-trifluoro-methylpyrimidines as side products. With method B, the side products were the corresponding>-formamidopyrimidines. KO side product was isolated when using method C 011 the 2-trifluoroniethyl compounds or when using any of the methods on the 6- trifluoromethyl series. X o attempt was made to cyclize the butylamino pyrimidines (111 ...