DNA Adduct Formation from Metabolic 5′-Hydroxylation of the Tobacco-Specific Carcinogen N′-Nitrosonornicotine in Human Enzyme Systems and in Rats

AT Zarth, P Upadhyaya, J Yang…

Index: Marriner, Gwendolyn A.; Kerwin, Sean M. Journal of Organic Chemistry, 2009 , vol. 74, # 7 p. 2891 - 2892

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Abstract

... All Publications/Website. Select a Journal or Book. ... Medicinal Chemistry Graduate Program ... 5′-Hydroxylation is also the major metabolic pathway in A/J mouse lung and in Syrian golden hamster trachea, which are two important target tissues of NNN tumorigenicity.(17-19). ...