Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. I. Design and Synthesis of (.+-.)-N-(2-(3, 4-Dichlorophenyl)-4-(spiro (isobenzofuran-1 (3H), 4'- …

H Kubota, M Fujii, K Ikeda, M TAKEUCHI…

Index: Chemical and Pharmaceutical Bulletin, , vol. 46, # 2 p. 351 - 354

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Citation Number: 25

Abstract

... Chemistry (i)-N-[2—(3,4~Dichlorophenyl)-4-(4-phenylpiperidi- no)butyl]-N-methylbenzamide (2) and (i)—N—[4 ... 1998 Pharmaceutical Society 01" Japan NII—Electronic Library Service ... Chemical shifts are given in ppm relative to that of Me4Si (6 : 0) in CDCl3 or dimethylsull'oxidc ...