Synthesis of (E)-8-(3-chlorostyryl) caffeine analogues leading to 9-deazaxanthine derivatives as dual A2A antagonists/MAO-B inhibitors

…, F Borsini, M Mor, G Tarzia, P Minetti

Index: Fuelle, Friederike; Mueller, Christa E. Heterocycles, 2000 , vol. 53, # 2 p. 347 - 351

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Citation Number: 23

Abstract

... Volume: Page ... a Reagents and conditions: (i) for 2a, (E)-PhCH═CHCO 2 H, POCl 3 , 140 °C, 5 h, 44%; for 2b, MeOH, AcOH, (E)-PhCH═CHCHO, rt, 1 ... a Reagents and conditions: (i) EtOH, N 3 CH 2 CO 2 Et, EtONa, 0 °C, 2h, 55–58%; (ii) p-xylene, 150 °C, 2 h, 78 ...