Total synthesis of (±)-rocaglamide via oxidation-initiated nazarov cyclization

JA Malona, K Cariou, WT Spencer III…

Index: Katamna,C. Bulletin de la Societe Chimique de France, 1970 , p. 2309 - 2322

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Citation Number: 32

Abstract

... This prevents de novo synthesis of c-FLIP, a protein that causes resistance to receptor-mediated apoptosis. ... The carbocation at C1 would be stabilized by both oxygen and the p-methoxybenzyl group (Scheme 7). With an electron-withdrawing ester at C4, C5 is also electrophilic ...