The Synthesis of 2-R-3, 3-Diphenyl-Δ1-pyrrolines from 2, 2-Diphenyl-4-bromobutyronitrile

PJA Demoen, PAJ Janssen

Index: Demoen; Janssen Journal of the American Chemical Society, 1959 , vol. 81, p. 6281,6283

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Citation Number: 8

Abstract

Murray and Cloke5 synthesized four (methyl-, ethyl-, n-propyl-and n-butyl-) Z-pheny1-3-alkyl- 3-phenyl-A'-pyrrolines from 4-chloro-2-alkyl-2-phenylbutyronitriles and phenylmagnesium bromide. As a rule, they refluxed the Grignard reagent and the nitrile for eight hours in ether, and added the cooled mixture to liquid ammonia. After evaporation of the ammonia, the 4l- pyrrolines were isolated from the residue. Yields were: CH3, 78%; CzH5, 70%; n-C3H7, ...