FEBS journal

On the thermodynamic equilibrium between (R)??2??hydroxyacyl??CoA and 2??enoyl??CoA

A Parthasarathy, W Buckel, DM Smith

Index: Parthasarathy, Anutthaman; Buckel, Wolfgang; Smith, David M. FEBS Journal, 2010 , vol. 277, # 7 p. 1738 - 1746

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Citation Number: 12

Abstract

Abstract A combined experimental and computational approach has been applied to investigate the equilibria between several α-hydroxyacyl-CoA compounds and their 2-enoyl- CoA derivatives. In contrast to those of their β, γ and δ counterparts, the equilibria for the α- compounds are relatively poorly characterized, but qualitatively they appear to be unusually sensitive to substituents. Using a variety of techniques, we have succeeded in measuring ...