Abstract: The folding of several depsipeptides constructed from a-amino acids [L-proline (P) and L-alanine (A)] and a-hydroxy acids [L-lactic acid (L) and glycolic acid (G)] has been examined in methylene chloride solution by variabletemperature IR spectroscopy. Additional studies have been conducted in some cases, involving variable-temperature'H NMR spectroscopy and molecular mechanics calculations. The depsipeptides include three- ...