Journal of the American Chemical Society

Hydrogen-bond-mediated folding in depsipeptide models of. beta.-turns and. alpha.-helical turns

EA Gallo, SH Gellman

Index: Gallo, Elizabeth A.; Gellman, Samuel H. Journal of the American Chemical Society, 1993 , vol. 115, # 21 p. 9774 - 9788

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Citation Number: 75

Abstract

Abstract: The folding of several depsipeptides constructed from a-amino acids [L-proline (P) and L-alanine (A)] and a-hydroxy acids [L-lactic acid (L) and glycolic acid (G)] has been examined in methylene chloride solution by variabletemperature IR spectroscopy. Additional studies have been conducted in some cases, involving variable-temperature'H NMR spectroscopy and molecular mechanics calculations. The depsipeptides include three- ...