Covalent inhibition of bacterial quorum sensing

N Amara, R Mashiach, D Amar, P Krief…

Index: Amara, Neri; Mashiach, Roi; Amar, Dotan; Krief, Pnina; Spieser, Stephane A. H.; Bottomley, Matthew J.; Aharoni, Amir; Meijler, Michael M. Journal of the American Chemical Society, 2009 , vol. 131, # 30 p. 10610 - 10619

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Citation Number: 115

Abstract

Chemical coordination of gene expression among bacteria as a function of population density is regulated by a mechanism known as 'quorum sensing'(QS). QS in Pseudomonas aeruginosa, an opportunistic pathogen that causes disease in immunocompromised patients, is mediated by binding of the transcriptional activator, LasR, to its ligand, 3-oxo- C12-HSL, leading to population-wide secretion of virulence factors and biofilm formation. ...