Multi??Enzymatic Biosynthesis of Chiral β??Hydroxy Nitriles through Co??Expression of Oxidoreductase and Halohydrin Dehalogenase

SY Chen, CX Yang, JP Wu, G Xu…

Index: Advanced Synthesis and Catalysis, , vol. 355, # 16 p. 3179 - 3190

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Citation Number: 9

Abstract

... Advanced Synthesis & Catalysis. ... In addition, (R)-3b, a key intermediate in the synthesis of fluoxetine, was obtained with Eco SFH; and (S)-3b, a key intermediate in the synthesis of atomoxetine, was obtained with Eco RBH. ... The gene hhdh was artificially synthesized by Takara. ...

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