Tetrahedron: Asymmetry

Asymmetric reduction of substituted α-and β-ketoesters by Bacillus pumilus Phe-C3

C He, D Chang, J Zhang

Index: He, Chunmao; Chang, Dongliang; Zhang, Jie Tetrahedron Asymmetry, 2008 , vol. 19, # 11 p. 1347 - 1351

Full Text: HTML

Citation Number: 26

Abstract

The enantioselective reduction of substituted α-and β-ketoesters using resting cells of Bacillus pumilus Phe-C3 was investigated. Effects of substrate concentration on the catalytic efficiency of the microorganism were studied. Preparative scale productions were carried out under the optimized conditions with 62.4–91.0% yields and 90.2–97.1% ee. The cells retained 80% of initial activity after recycling for six times.