The asymmetric total synthesis of (+)-hirsutene from the regio-and enantioselective 1, 4-y- addition reaction of (-)-(S)-allyl p-tolyl sulfoxide and 2-methyl-2-cyclopentenone is presented. In this total synthesis, a facile ring closure reaction involving enol thioether and enol acetate moieties and the deoxygenation reaction of a highly hindered secondary alcohol via its 2-propanesulfonate were found. An unexpected displacement reaction at ...
