e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Novel Series of Potent, Nonsteroidal, Selective Androgen Receptor Modulators Based on 7 H-[1, 4] Oxazino [3, 2-g] quinolin-7-ones

…, YO Long, TK Jones, JP Edwards, L Zhi…

Index: Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K. Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639

Full Text: HTML

Citation Number: 38

Abstract

Recent interest in orally available androgens has fueled the search for new androgens for use in hormone replacement therapy and as anabolic agents. In pursuit of this, we have discovered a series of novel androgen receptor modulators derived from 7 H-[1, 4] oxazino [3, 2-g] quinolin-7-ones. These compounds were synthesized and evaluated in competitive binding assays and an androgen receptor transcriptional activation assay. A number of ...

2,2-Dimethyl-1,2-dihydro-quinoline Structure

2,2-Dimethyl-1,...

~98%

2,2-dimethyl-1,2,3,4-tetrahydro-quinoline Structure

2,2-dimethyl-1,...

N-(2-methylbut-3-yn-2-yl)aniline Structure

N-(2-methylbut-...

~%

2,2-dimethyl-1,2,3,4-tetrahydro-quinoline Structure

2,2-dimethyl-1,...

tert-butyl 3-nitrophenylcarbamate Structure

tert-butyl 3-ni...

~%

7-Quinolinamine,1,2-dihydro-2,2,4-trimethyl- Structure

7-Quinolinamine...

3-Nitroaniline Structure

~%

7-Quinolinamine,1,2-dihydro-2,2,4-trimethyl- Structure

7-Quinolinamine...

tert-butyl (2,2,4-trimethyl-1,2-dihydroquinolin-7-yl)carbamate Structure

tert-butyl (2,2...

~%

7-Quinolinamine,1,2-dihydro-2,2,4-trimethyl- Structure

7-Quinolinamine...

N-Boc-m-phenylenediamine Structure

N-Boc-m-phenyle...

~%

7-Quinolinamine,1,2-dihydro-2,2,4-trimethyl- Structure

7-Quinolinamine...

3-Methyl butynol Structure

3-Methyl butynol

~%

N-(2-methylbut-3-yn-2-yl)aniline Structure

N-(2-methylbut-...

3-Butyn-2-ol,2-methyl-, 2-acetate Structure

3-Butyn-2-ol,2-...

Structure

~%

N-(2-methylbut-3-yn-2-yl)aniline Structure

N-(2-methylbut-...

N-(2-methylbut-3-yn-2-yl)aniline Structure

N-(2-methylbut-...

~74%

2,2-Dimethyl-1,2-dihydro-quinoline Structure

2,2-Dimethyl-1,...

7'-nitro-3',4'-dihydro-1'H-spiro[cyclohexane-1,2'-quinoline] Structure

7'-nitro-3',4'-...

~%

3',4'-dihydro-1'H-spiro[cyclohexane-1,2'-quinolin]-7'-aMine Structure

3',4'-dihydro-1...

3',4'-dihydro-1'H-spiro[cyclohexane-1,2'-quinoline] Structure

3',4'-dihydro-1...

~%

3',4'-dihydro-1'H-spiro[cyclohexane-1,2'-quinolin]-7'-aMine Structure

3',4'-dihydro-1...

Cyclohexanol,1-ethynyl-, 1-acetate Structure

Cyclohexanol,1-...

~%

3',4'-dihydro-1'H-spiro[cyclohexane-1,2'-quinolin]-7'-aMine Structure

3',4'-dihydro-1...

N-(1-Ethinylcyclohexyl)anilin Structure

N-(1-Ethinylcyc...

~%

3',4'-dihydro-1'H-spiro[cyclohexane-1,2'-quinolin]-7'-aMine Structure

3',4'-dihydro-1...

Structure

~%

3',4'-dihydro-1'H-spiro[cyclohexane-1,2'-quinolin]-7'-aMine Structure

3',4'-dihydro-1...

1'H-spiro[cyclohexane-1,2'-quinoline] Structure

1'H-spiro[cyclo...

~%

3',4'-dihydro-1'H-spiro[cyclohexane-1,2'-quinolin]-7'-aMine Structure

3',4'-dihydro-1...

N-(2-methylbut-3-yn-2-yl)aniline Structure

N-(2-methylbut-...

~%

tert-butyl 2,2-dimethylquinoline-1(2H)-carboxylate Structure

tert-butyl 2,2-...

2,2-Dimethyl-1,2-dihydro-quinoline Structure

2,2-Dimethyl-1,...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

tert-butyl 2,2-dimethylquinoline-1(2H)-carboxylate Structure

tert-butyl 2,2-...

2,2-dimethyl-1,2,3,4-tetrahydro-quinoline Structure

2,2-dimethyl-1,...

~%

7-amino-1,2,3,4-tetrahydro-2,2-dimethylquinoline Structure

7-amino-1,2,3,4...

2,2-Dimethyl-1,2-dihydro-quinoline Structure

2,2-Dimethyl-1,...

~%

7-amino-1,2,3,4-tetrahydro-2,2-dimethylquinoline Structure

7-amino-1,2,3,4...

N-(2-methylbut-3-yn-2-yl)aniline Structure

N-(2-methylbut-...

~%

7-amino-1,2,3,4-tetrahydro-2,2-dimethylquinoline Structure

7-amino-1,2,3,4...