Discovery of imidazo [1, 2-a] pyrazine-based Aurora kinase inhibitors

DB Belanger, PJ Curran, A Hruza, J Voigt…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 17 p. 5170 - 5174

Full Text: HTML

Citation Number: 32

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Medicinal chemistry efforts commenced by simultaneously investigating the SARs at the 3-, 6- and 8-positions ... 46%; (e) m-CPBA, DCM, rt, 95%; (f) NaH, 5-amino-3-methyl isothiazole hydrochloride, DMSO, rt, 56%; (g) chemistry varies; ( ...