Magnesium perchlorate as efficient Lewis acid for the Knoevenagel condensation between β-diketones and aldehydes

…, A Carlone, R Dalpozzo, P Galzerano, P Melchiorre…

Index: Bartoli, Giuseppe; Bosco, Marcella; Carlone, Armando; Dalpozzo, Renato; Galzerano, Patrizia; Melchiorre, Paolo; Sambri, Letizia Tetrahedron Letters, 2008 , vol. 49, # 16 p. 2555 - 2557

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Citation Number: 59

Abstract

The classical Knoevenagel condensation (Scheme 1) has been carried out by reacting a methylene active compound with an aldehyde or a ketone in the presence of a base. 1 and 3 Recently, alternative procedures employed heterogeneous catalysts, such as zeolites, 4 clays, 5 layered double hydroxides (LDHs), 6 and hydrotalcites. 7 Various protocols carried out in ionic liquids 8 have also been developed. On the contrary, relatively few examples of condensation mediated by Lewis ...