Synthetic communications

New synthesis of thymidylate synthase inhibitor raltitrexed

SL Cao, R Wan, YP Feng

Index: Synthetic Communications, , vol. 33, # 20 p. 3519 - 3526

Full Text: HTML

Citation Number: 7

Abstract

... Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry. ... The mild conditions utilized in the synthetic route avoid the use of n-BuLi, NaH and the experimental conditions of low temperature at −78°C and strictly free of water ...

 Related Synthetic Route
Thiophene-2,5-dicarboxylic acid Structure

4282-31-9

Thiophene-2,5-d...

~%

Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Structure

112889-02-8

Diethyl N-[5-me...

diethyl glutamate Structure

16450-41-2

diethyl glutamate

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Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Structure

112889-02-8

Diethyl N-[5-me...

5-[[(2S)-1,5-diethoxy-1,5-dioxopentan-2-yl]carbamoyl]thiophene-2-carboxylic acid Structure

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5-[[(2S)-1,5-di...

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Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Structure

112889-02-8

Diethyl N-[5-me...

diethyl N-[5-[N-(tert-butoxycarbonyl)amino]-2-thenoyl]-L-glutamate Structure

651295-44-2

diethyl N-[5-[N...

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Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Structure

112889-02-8

Diethyl N-[5-me...

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate Structure

132463-02-6

Diethyl N-[5-[N...

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Raltitrexed Structure

112887-68-0

Raltitrexed

6-(Bromomethyl)-2-methyl-4(1H)-quinazolinone Structure

112888-43-4

6-(Bromomethyl)...

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Raltitrexed Structure

112887-68-0

Raltitrexed

Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Structure

112889-02-8

Diethyl N-[5-me...

~%

Raltitrexed Structure

112887-68-0

Raltitrexed

diethyl N-[5-[N-(tert-butoxycarbonyl)-N-methylamino]-2-thenoyl]-L-glutamate Structure

132463-33-3

diethyl N-[5-[N...

~%

Raltitrexed Structure

112887-68-0

Raltitrexed

Thiophene-2,5-dicarboxylic acid Structure

4282-31-9

Thiophene-2,5-d...

~%

Raltitrexed Structure

112887-68-0

Raltitrexed

diethyl glutamate Structure

16450-41-2

diethyl glutamate

~%

Raltitrexed Structure

112887-68-0

Raltitrexed

5-[[(2S)-1,5-diethoxy-1,5-dioxopentan-2-yl]carbamoyl]thiophene-2-carboxylic acid Structure

651295-42-0

5-[[(2S)-1,5-di...

~%

Raltitrexed Structure

112887-68-0

Raltitrexed

diethyl N-[5-[N-(tert-butoxycarbonyl)amino]-2-thenoyl]-L-glutamate Structure

651295-44-2

diethyl N-[5-[N...

~%

Raltitrexed Structure

112887-68-0

Raltitrexed

diethyl N-[5-[N-(tert-butoxycarbonyl)-N-methylamino]-2-thenoyl]-L-glutamate Structure

132463-33-3

diethyl N-[5-[N...

~%

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate Structure

132463-02-6

Diethyl N-[5-[N...

Thiophene-2,5-dicarboxylic acid Structure

4282-31-9

Thiophene-2,5-d...

~%

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate Structure

132463-02-6

Diethyl N-[5-[N...

diethyl glutamate Structure

16450-41-2

diethyl glutamate

~%

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate Structure

132463-02-6

Diethyl N-[5-[N...

5-[[(2S)-1,5-diethoxy-1,5-dioxopentan-2-yl]carbamoyl]thiophene-2-carboxylic acid Structure

651295-42-0

5-[[(2S)-1,5-di...

~%

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate Structure

132463-02-6

Diethyl N-[5-[N...

diethyl N-[5-[N-(tert-butoxycarbonyl)amino]-2-thenoyl]-L-glutamate Structure

651295-44-2

diethyl N-[5-[N...

~%

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate Structure

132463-02-6

Diethyl N-[5-[N...


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