Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

PR Marsham, LR Hughes, AL Jackman…

Index: Journal of Medicinal Chemistry, , vol. 34, # 5 p. 1594 - 1605

Full Text: HTML

Citation Number: 100

Abstract

... Institute of Cancer Research. f Present address: Cancer Research Unit, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, England. 0022-262319111834-1594$02.50/ 0 COpH I ... Scheme Io Journal of Medicinal Chemistry, 1991, Vol. 34, No. 5 1696 ...

 Related Synthetic Route
5-Nitrothiophene-2-carbonyl Chloride Structure

39978-57-9

5-Nitrothiophen...

~%

Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Structure

112889-02-8

Diethyl N-[5-me...

H-Glu(OEt)-OEt.HCl Structure

1118-89-4

H-Glu(OEt)-OEt.HCl

~%

Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Structure

112889-02-8

Diethyl N-[5-me...

tert-Butyl methyl(thiophen-2-yl)carbamate Structure

132463-32-2

tert-Butyl meth...

~%

Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Structure

112889-02-8

Diethyl N-[5-me...

5-[N-(tert-butoxycarbonyl)-N-methylamino]-2-thiophenecarboxylic acid Structure

131052-68-1

5-[N-(tert-buto...

~%

Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Structure

112889-02-8

Diethyl N-[5-me...

diethyl N-(5-nitro-2-thienoyl)-L-glutamate Structure

106585-64-2

diethyl N-(5-ni...

~%

Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate Structure

112889-02-8

Diethyl N-[5-me...

5-Nitrothiophene-2-carbonyl Chloride Structure

39978-57-9

5-Nitrothiophen...

~%

Raltitrexed Structure

112887-68-0

Raltitrexed

H-Glu(OEt)-OEt.HCl Structure

1118-89-4

H-Glu(OEt)-OEt.HCl

~%

Raltitrexed Structure

112887-68-0

Raltitrexed

tert-Butyl methyl(thiophen-2-yl)carbamate Structure

132463-32-2

tert-Butyl meth...

~%

Raltitrexed Structure

112887-68-0

Raltitrexed

5-[N-(tert-butoxycarbonyl)-N-methylamino]-2-thiophenecarboxylic acid Structure

131052-68-1

5-[N-(tert-buto...

~%

Raltitrexed Structure

112887-68-0

Raltitrexed

N/A Structure

106585-63-1

N/A

~%

Raltitrexed Structure

112887-68-0

Raltitrexed

diethyl N-(5-nitro-2-thienoyl)-L-glutamate Structure

106585-64-2

diethyl N-(5-ni...

~%

Raltitrexed Structure

112887-68-0

Raltitrexed

5-Nitrothiophene-2-carbonyl Chloride Structure

39978-57-9

5-Nitrothiophen...

~%

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate Structure

132463-02-6

Diethyl N-[5-[N...

H-Glu(OEt)-OEt.HCl Structure

1118-89-4

H-Glu(OEt)-OEt.HCl

~%

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate Structure

132463-02-6

Diethyl N-[5-[N...

tert-Butyl methyl(thiophen-2-yl)carbamate Structure

132463-32-2

tert-Butyl meth...

~%

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate Structure

132463-02-6

Diethyl N-[5-[N...

5-[N-(tert-butoxycarbonyl)-N-methylamino]-2-thiophenecarboxylic acid Structure

131052-68-1

5-[N-(tert-buto...

~%

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate Structure

132463-02-6

Diethyl N-[5-[N...

N/A Structure

106585-63-1

N/A

~%

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate Structure

132463-02-6

Diethyl N-[5-[N...

diethyl N-(5-nitro-2-thienoyl)-L-glutamate Structure

106585-64-2

diethyl N-(5-ni...

~%

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate Structure

132463-02-6

Diethyl N-[5-[N...

Thiophene-2-carboxylic acid Structure

527-72-0

Thiophene-2-car...

tert-Butanol Structure

75-65-0

tert-Butanol

~92%

Tert-Butyl N-(2-Thienyl)Carbamate Structure

56267-50-6

Tert-Butyl N-(2...


Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved