Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii

…, J Żebrowska, L Chomicz, J Piekarczyk, P Myjak…

Index: Kopanska, Katarzyna; Najda, Andzelika; Zebrowska, Justyna; Chomicz, Lidia; Piekarczyk, Janusz; Myjak, Przemyslaw; Bretner, Maria Bioorganic and Medicinal Chemistry, 2004 ,  vol. 12,  # 10  p. 2617 - 2624

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Citation Number: 103

Abstract

Chloro-, bromo-and methyl-analogues of 1H-benzimidazole and 1H-benzotriazole and their N-alkyl derivatives have been synthesized and tested in vitro against the protozoa Acanthamoeba castellanii. The results indicate that 5, 6-dimethyl-1H-benzotriazole (11) and 5, 6-dibromo-1H-benzotriazole (14) have higher efficacy than the antiprotozoal agent chlorohexidine.