Direct transformation of secondary amides into secondary amines: triflic anhydride activated reductive alkylation

KJ Xiao, AE Wang, PQ Huang

Index: Xiao, Kai-Jiong; Wang, Ai-E; Huang, Pei-Qiang Angewandte Chemie - International Edition, 2012 , vol. 51, # 33 p. 8314 - 8317

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Citation Number: 58

Abstract

Amines are an important class of compounds that constitute the major body of bioactive natural products (alkaloids) and pharmaceuticals.[1] Amides are a class of easily available and highly stable compounds.[2] Consequently, the synthesis of amines by reductive alkylation of amides is of high relevance in organic synthesis,[3] and has been the focus of recent research.[4–6] The transformation of tertiary amides into amines has been ...