e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Rearrangement of propargylic esters: Metal-based stereospecific synthesis of (E)-and (Z)-Knoevenagel derivatives
…, L Riesgo, R Vicente, LA López, M Tomás
Index: Barluenga, Jose; Riesgo, Lorena; Vicente, Ruben; Lopez, Luis A.; Tomas, Miguel Journal of the American Chemical Society, 2007 , vol. 129, # 25 p. 7772 - 7773
Alkoxy-substituted propargylic esters undergo regioselective 1, 3-acyloxy migration in the presence of Pt (II) and Cu (I) catalysts, allowing the preparation of α-ylidene-β-keto and- malonate esters. The reaction proved to also be stereodivergent as the Pt (II) and the Cu (I) catalysts perform the isomerization with complementary Z/E selectivity. Moreover, alkynyl- conjugated Knoevenagel products are produced from (bisalkynyl) methyl acetates. In such ...