Regioselective synthesis of multisubstituted furans via metalloradical cyclization of alkynes with α-diazocarbonyls: construction of functionalized α-oligofurans

…, X Xu, L Wojtas, MM Kim, XP Zhang

Index: Cui, Xin; Xu, Xue; Wojtas, Lukasz; Kim, Martin M.; Zhang, X. Peter Journal of the American Chemical Society, 2012 , vol. 134, # 49 p. 19981 - 19984

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Citation Number: 74

Abstract

Co (III)–carbene radicals generated from activation of α-diazocarbonyls by Co (II)–porphyrin complexes have been shown to undergo a new type of tandem radical addition reaction with alkynes that affords five-membered furan structures. The Co (II) complex of 3, 5-Di t Bu- IbuPhyrin,[Co (P1)], is effective in catalyzing the metalloradical cyclization reaction under neutral and mild conditions. The [Co (P1)]-catalyzed process tolerates a wide range of α- ...