Synthesis of Optically Active N??Aryl Amino Acid Derivatives through the Asymmetric Petasis Reaction Catalyzed by a Novel Hydroxy–Thiourea Catalyst

…, Y Suzuki, T Sakaeda, Y Takemoto

Index: Inokuma, Tsubasa; Suzuki, Yusuke; Sakaeda, Toshiyuki; Takemoto, Yoshiji Chemistry - An Asian Journal, 2011 , vol. 6, # 11 p. 2902 - 2906

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Citation Number: 19

Abstract

Optically active nonproteinogenic amino acid derivatives have received considerable interest due to their biological activities and ability to serve as chiral building blocks in asymmetric synthesis. N-Aryl-substituted amino acid derivatives can act as a fibrinogen receptor antagonist,[1] hepatitis C virus replication inhibitor,[2] glycine antagonist [3] or an angiotensin receptor antagonist [4] as shown in Figure 1. In addition, it is known that some ...