Il Farmaco

A novel sunscreen agent having antimelanoma activity

MA Nogueira, EG Magalhães, AF Magalhães, DN Biloti…

Index: Nogueira, Marisa A.; Magalhaes, Eva G.; Magalhaes, Aderbal F.; Biloti, Debora N.; Laverde Jr., Antonio; Pessine, Francisco B.T.; Carvalho, Joao E.; Kohn, Luciana K.; Antonio, Marcia A.; Marsaioli, Anita J. Farmaco, 2003 , vol. 58, # 11 p. 1163 - 1169

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Citation Number: 19

Abstract

A novel series of eight dibenzoylmethane derivatives having both sunscreen and cytotoxic activity has been obtained by derivatizing commercial dibenzoyl methanes. Four human cancer cell lines (MCF 7 (breast), NCI ADR (breast expressing the multidrug resistance phenotype), NCI 460 (lung) and UACC 62 (melanoma)) were used for the cytotoxic assay. Eight among the 19 dibenzoylmethane derivatives showed cytotoxicity against these four ...