C–N bond cleavage of allylic amines via hydrogen bond activation with alcohol solvents in Pd-catalyzed allylic alkylation of carbonyl compounds

…, D Liu, H Guo, Y Liu, W Zhang

Index: Zhao, Xiaohu; Liu, Delong; Guo, Hui; Liu, Yangang; Zhang, Wanbin Journal of the American Chemical Society, 2011 , vol. 133, # 48 p. 19354 - 19357

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Citation Number: 102

Abstract

Hydrogen-bond-activated C–N bond cleavage of allylic amines was realized in Pd-catalyzed allylic alkylation to form the C–C bond product. The method could be expanded to a series of allylic amines and carbonyl compounds with excellent results. It provides a new and convenient access to C–C bond formation based on Pd-catalyzed allylic alkylation of allylic amines by using only inexpensive alcohol solvents.