Tetrahedron

Synthesis of 1, 2-dihydro-1, 3-diaza-2λ 5, 4λ 5-2, 4-diphosphorine 2-oxides

CM Andújar, IP Álvarez, FL Ortiz

Index: Andujar, Carmen M; Alvarez, Isidro Perez; Ortiz, Fernando Lopez Tetrahedron, 2002 , vol. 58, # 13 p. 2569 - 2575

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Citation Number: 12

Abstract

The reaction of lithium (N-diphenylphosphoryl) phosphazenes with nitriles afforded 1, 2- dihydro-1, 3-diaza-2λ5, 4λ5-2, 4-diphosphorine 2-oxides through a C-regioselective addition to the cyano linkage followed by in situ cyclocondensation. The new heterocycles were designed to mimic thymine and are promising chemotherapeutic anticancer agents. As an exception, for p-nitrobenzonitrile a SNAr reaction was exclusively observed with the ...