UVA light-induced DNA cleavage by isomeric methylbenz [a] anthracenes

…, RN Shirsat, HM Hwang, J Leszczynski…

Index: Dong, Shiming; Fu, Peter P.; Shirsat, Rujendra N.; Hwang, Huey-Min; Leszczynski, Jerzy; Yu, Hongtao Chemical Research in Toxicology, 2002 , vol. 15, # 3 p. 400 - 407

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Citation Number: 40

Abstract

UVA light-induced DNA single strand cleavage by a set of 12 monomethyl substituted benz [a] anthracenes (MBAs) along with their parent compound, benz [a] anthracene (BA), and the potent carcinogen, 7, 12-dimethylbenz [a] anthracene (DMBA), was studied. On the basis of the relative DNA single strand photocleavage efficiency of the fourteen compounds, they are divided into three groups:(1) strong DNA cleavers, 4-MBA, 5-MBA, 6-MBA, 8-MBA, 9-MBA, ...