e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis of a series of novel polycyclic aromatic systems: Isomers of benz [a] anthracene containing a cyclopenta-fused ring

R Sangaiah, A Gold, GE Toney

Index: Sangaiah, R.; Gold, A.; Toney, G. E. Journal of Organic Chemistry, 1983 , vol. 48, # 10 p. 1632 - 1638

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Citation Number: 45

Abstract

The four possible isomers of benz [a] anthracene containing a cyclopenta-fused ring have been synthesized and characterized. Thew systems are of interest for structureactivity studies in bioactivation because of their predicted high level of activity. Formation of fused five-membered rings by intramolecular cyclodehydration, often difficult to accomplish, was found to be smoothly effected in anhydrous HF, provided the reactivity index (Nt) for the ...

7-CHLOROMETHYL BENZ(a)ANTHRACENE Structure

7-CHLOROMETHYL ...

~85%

Benz[a]anthracene-7-acetonitrile Structure

Benz[a]anthrace...

Benz[a]anthracene-7-acetonitrile Structure

Benz[a]anthrace...

~85%

Benz[a]anthracene-7-acetic acid Structure

Benz[a]anthrace...

7-CHLOROMETHYL BENZ(a)ANTHRACENE Structure

7-CHLOROMETHYL ...

~%

Benz[a]anthracene-7-acetic acid Structure

Benz[a]anthrace...

5-methylbenzo[a]anthracene-7,12-dione Structure

5-methylbenzo[a...

~96%

5-Methyltetraphene Structure

5-Methyltetraphene

1,2-dihydrocyclopenta[no]tetraphen-1-ol Structure

1,2-dihydrocycl...

~%

Benzaceanthrylene Structure

Benzaceanthrylene

5,8,9,10-Tetrahydro-11(6H)-tetraphenone Structure

5,8,9,10-Tetrah...

~%

Benzaceanthrylene Structure

Benzaceanthrylene

4,5-Dihydrobenz[k]acephenanthrylenequinone Structure

4,5-Dihydrobenz...

~99%

4,5-DIHYDRO-BENZ(K)ACEPHENANTHRYLENE Structure

4,5-DIHYDRO-BEN...

2-(4-methylnaphthalene-1-carbonyl)benzoic acid Structure

2-(4-methylnaph...

~52%

5-methylbenzo[a]anthracene-7,12-dione Structure

5-methylbenzo[a...

HIV-1 Nef-IN-1 Structure

~69%

Benz[a]anthracen-8(9H)-one, 10,11-dihydro- Structure

Benz[a]anthrace...

1-Hydroxy-1,2-dihydrobenz[j]aceanthrylene Structure

1-Hydroxy-1,2-d...

~62%

benzo[j]aceanthrylene Structure

benzo[j]aceanth...

4,5-DIHYDRO-BENZ(K)ACEPHENANTHRYLENE Structure

4,5-DIHYDRO-BEN...

~71%

benz[k]acephenanthrylene Structure

benz[k]acephena...

4,5-dihydrocyclopenta[de]tetraphen-4-ol Structure

4,5-dihydrocycl...

~%

benz[k]acephenanthrylene Structure

benz[k]acephena...

5-methylbenzo[a]anthracene-7,12-dione Structure

5-methylbenzo[a...

~%

benz[k]acephenanthrylene Structure

benz[k]acephena...

5-Methyltetraphene Structure

5-Methyltetraphene

~%

benz[k]acephenanthrylene Structure

benz[k]acephena...

Ethyl-1,2-benzanthracen-5-acetat Structure

Ethyl-1,2-benza...

~90%

Benz[a]anthracene-8-acetic acid Structure

Benz[a]anthrace...

Benz[a]anthracen-8(9H)-one, 10,11-dihydro- Structure

Benz[a]anthrace...

~%

Benz[a]anthracene-8-acetic acid Structure

Benz[a]anthrace...

HIV-1 Nef-IN-1 Structure

~%

Benz[a]anthracene-8-acetic acid Structure

Benz[a]anthrace...

ethyl 2-(8-hydroxy-8,9,10,11-tetrahydrotetraphen-8-yl)acetate Structure

ethyl 2-(8-hydr...

~%

Benz[a]anthracene-8-acetic acid Structure

Benz[a]anthrace...