Tetrahedron letters

2, 5-Disubstituted furans from 1, 4-alkynediols

SJ Pridmore, PA Slatford, JMJ Williams

Index: Pridmore, Simon J.; Slatford, Paul A.; Williams, Jonathan M.J. Tetrahedron Letters, 2007 , vol. 48, # 29 p. 5111 - 5114

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Citation Number: 38

Abstract

1, 4-Alkynediols serve as readily available starting materials for isomerisation to 1, 4- diketones, which can be converted in situ into the corresponding furans by acid-catalysed dehydration. A range of 2, 5-disubstituted furans was prepared using the ruthenium-based catalyst Ru (PPh3) 3 (CO) H2 with Xantphos at 1mol% loading.