RSC Advances

An organocatalyst from renewable materials for the synthesis of coumarins and chromenes: three-component reaction and multigram scale synthesis

…, T Aree, C Mahidol, S Ruchirawat, P Kittakoop

Index: Sangsuwan, Rapeepat; Sangher, Sasithorn; Aree, Thammarat; Mahidol, Chulabhorn; Ruchirawat, Somsak; Kittakoop, Prasat RSC Advances, 2014 , vol. 4, # 26 p. 13708 - 13718

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Citation Number: 10

Abstract

A new concept of catalysts which are prepared from renewable materials is demonstrated. It is known that amino acids (eg, proline and hydroxyproline) are robust organocatalysts for several reactions. Bovine tendons which are proteins rich in hydroxyproline and proline were used as a source of amino acids. An acid hydrolysate of tendons (a TH catalyst) could catalyze two reactions:(i) the synthesis of coumarins and chromenes under solvent-free ...