A convenient method for the synthesis of a series of 4-trichloromethyl-pyrimidin-2-ylamines from the reaction of 4-trichloromethyl-2-chloropyrimidine and ammonium hydroxide, primary- and secondary-amines, and guanidine hydrochloride, is reported. This reactions was also extended to obtain 4-trichloromethyl-2-alkoxy-pyrimidines.
![2-[4-(trichloromethyl)pyrimidin-2-yl]guanidine Structure](https://image.chemsrc.com/caspic/067/380305-28-2.png)