Tetrahedron

A highly efficient synthesis of civetone

R Hamasaki, S Funakoshi, T Misaki, Y Tanabe

Index: Hamasaki, Ryota; Funakoshi, Syunsuke; Misaki, Tomonori; Tanabe, Yoo Tetrahedron, 2000 , vol. 56, # 38 p. 7423 - 7425

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Citation Number: 25

Abstract

A highly efficient synthesis of civetone has been performed by joining two crucial reactions;(a) Ti-Claisen condensation and (b) intramolecular olefin metathesis using Grubbs' reagent. This synthesis includes not only a stepwise method (A) but also a one-pot method (B).