Abstract The present work involved the synthesis of chalcone derivatives, their characterization and in vitro evaluation for lipoxygenase inhibitory activity. The synthesis of chalcone derivatives was carried out in one step employing Claisen Schmidt condensation. Different substituted benzaldehydes viz., 3, 4, 5-trimethoxy benzaldehyde, ortho-, meta-and para-benzaldehyde, orthobromobenzaldehyde, ortho-and para-methyl benzaldehyde, ...