Guanine-rich RNAs and DNAs that bind heme robustly catalyze oxygen transfer reactions

LCH Poon, SP Methot, W Morabi-Pazooki…

Index: Poon, Lester C.-H.; Methot, Stephen P.; Morabi-Pazooki, William; Pio, Frederic; Bennet, Andrew J.; Sen, Dipankar Journal of the American Chemical Society, 2011 , vol. 133, # 6 p. 1877 - 1884

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Citation Number: 46

Abstract

Diverse guanine-rich RNAs and DNAs that fold to form guanine quadruplexes are known to form tight complexes with Fe (III) heme. We show here that a wide variety of such complexes robustly catalyze two-electron oxidations, transferring oxygen from hydrogen peroxide to thioanisole, indole, and styrene substrates. Use of 18O-labeled hydrogen peroxide reveals the source of the oxygen transferred to form thioanisole sulfoxide and styrene oxide to be ...