Because of the involvement of farnesylated proteins in oncogenesis, inhibition of the protein- modifying enzyme farnesyltransferase is considered a major emerging strategy in cancer therapy. Here, we describe the structure-activity relationship of a novel class of CAAX- peptidomimetic farnesyltransferase inhibitors based on the benzophenone scaffold. 4'- Methyl, 4'-chloro, 4'-bromo, and 4'-nitrophenylacetic acid as substituents at the 2-amino ...
