Rearrangement of di-t-butyl aryl phosphates to di-t-butyl (2-hydroxyaryl) phosphonates. Preparation of (2-hydroxy-1, 3-phenylene) bisphosphonic acids

B Dhawan, D Redmore

Index: Dhavan, Balram; Redmore, Derek Phosphorus, Sulfur and Silicon and the Related Elements, 1989 , vol. 42, p. 177 - 182

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Citation Number: 11

Abstract

Abstract Di-t-butyl aryl phosphates 3 on treatment with lithium diisopropylamide rearrange to di-t-butyl (2-hydroxyaryl) phosphonates 5. A di-t-butyl (2-hydroxyaryl) phosphonate on reaction with di-t-butyl phosphorochloridate yields a phosphate-phosphonate 8 which on treatment with lithium diisopropylamide gives a tetra-t-butyl (2-hydroxy-1, 3-arenediyl) bisphosphonate 10. Treatment of these phosphonate esters 5 and 10 with trifluoroacetic ...