One-pot three-component synthesis of indole-3-glyoxyl derivatives and indole-3-glyoxyl triazoles

…, FB Souza, F Manarin, J Zukerman-Schpector

Index: Stefani, Helio A.; Vasconcelos, Stanley N.S.; Souza, Frederico B.; Manarin, Flavia; Zukerman-Schpector, Julio Tetrahedron Letters, 2013 , vol. 54, # 43 p. 5821 - 5825

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Citation Number: 9

Abstract

Abstract A general and efficient reaction of indole with oxalyl chloride and nucleophiles providing indole-3-glyoxyl derivatives has been developed in mild conditions. In the same fashion, the other reaction involved the addition of organic azides leading to the synthesis of indole-3-glyoxyl-1, 2, 3-triazoles, which proceeds smoothly generating the products in moderate to high yields.