Synthesis and properties of 4-amino-5-(5-X-2-furyl) thiazole derivatives

…, A Jurášek, J Kováč, VG Kul'nevich

Index: Krapivin, Gennadii D.; Jurasek, Adolf; Kovac, Jaroslav; Kul'nevich, Vladimir G. Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 10 p. 2285 - 2294

Full Text: HTML

Citation Number: 8

Abstract

Abstract Reaction of dipotassium cyanimidodithiocarbonate ((KS) 2 C= N-CN) with 5-X- furfuryl halogenides (X= NO 2, CHO) and 4-nitrobenzyl bromide gives the substituted esters which, in alkali medium, gives the carbanions undergoing cyclization to 4-amino-5-(5-X-2- furyl) thiazoles and 4-amino-5-(4-nitrophenyl)-2-(4-nitrobenzylthio) thiazole, respectively. Reaction of 5-X-furfuryl halogenides or 4-nitrobenzyl bromide with potassium methyl ...