A Tröger's base derivative (5, 12-dimethyl-3, 10-diphenyl-1, 3, 4, 8, 10, 11-hexaazatetracyclo [6.6. 1.02, 6.09, 13] pentadeca-2 (6), 4, 9 (13), 11-tetraenes) was used as an efficient catalyst for the three-component Mannich reactions of aromatic aldehydes and aromatic amines with ketones in water at room temperature. This rapid reaction afforded the corresponding β- amino ketones in good yields with excellent stereoselectivity.
[Zahouily, Mohamed; Mounir, Bahija; Cherki, Hind; Bahlaouan, Bouchaib; Rayadh, Ahmed; Sebti, Said Phosphorus, Sulfur and Silicon and the Related Elements, 2007 , vol. 182, # 6 p. 1203 - 1217]
