A series of 2, 3-diaminopropionanilides was synthesized by acylation of mono-and disubstituted aniline derivatives with 2, 3-dibromopropionyl chloride and subsequent amination with the appropriate secondary amines. The target compounds were evaluated in mice for antiarrhythmic efficacy against chloroform-induced tachycardia and for central nervous system toxicity. Several of the active agents were found to have much higher ...
