Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines

…, S Genovese, B Lallemand, A Ionescu-Motatu…

Index: Bruyre, Celine; Genovese, Salvatore; Lallemand, Benjamin; Ionescu-Motatu, Alexandra; Curini, Massimo; Kiss, Robert; Epifano, Francesco Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 14 p. 4174 - 4179

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Citation Number: 29

Abstract

Abstract A series of 25 selected oxyprenylated natural phenylpropanoids were synthesized, and their growth inhibitory activities were evaluated in vitro together with 14 other commercially available non-alkylated compounds belonging to the same chemical series. The compounds were tested on six human cancer cell lines using MTT colorimetric assays. The data reveal that of the six chemical groups (G) studied, coumarins (G1), cinnamic and ...