Tetrahedron: Asymmetry

Two step synthesis of C 2 symmetric 2, 6-diaryl-alkyloxybenzaldehydes—a mitsunobu approach

JRL Smith, P O'Brien, G Reginato

Index: Smith, John R. Lindsay; O'Brien, Peter; Reginato, Gloriana Tetrahedron Asymmetry, 1997 , vol. 8, # 20 p. 3415 - 3420

Full Text: HTML

Citation Number: 9

Abstract

A simple two step method for the synthesis of three novel C2 symmetric 2, 6- diarylalkyloxybenzaldehydes is described. Starting from resorcinol, the route involves double Mitsunobu reaction with chiral alcohols followed by regiospecific lithiation and formylation.