Syntheses and Configurations of Some Thiomorpholide S??Oxides, Trithiozine Metabolites

C Farina, M Visconti, P Ventura, M Pinza…

Index: Farina; Visconti; Ventura; et al. Archiv der Pharmazie, 1981 , vol. 314, # 11 p. 932 - 937

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Abstract

Abstract Two metabolites of trithiozine, namely 4-(3, 5-dimethoxy-4-hydroxythiobenzoyl) morpholine S-oxide (2a) and 4-(3, 4, 5-trimethoxythiobenzoyl) morpholine S-oxide (2b), were synthesized by oxidation of the thioamides 1a, b or, in the case of 2b, by reaction of E- and Z-(3, 4, 5-trimethoxyphenyl)(methylthio) sulfine (4) with morpholine. Both procedures afford the compounds 2a, b as single isomers having the same configuration at the sulfine ...