Description |
Trithiozine is an orally active antisecretory and antiulcer agent. Trithiozine can be used for the research of peptic ulcer disease and hypersecretory disorders[1].
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Related Catalog |
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In Vivo |
Trithiozine (T) (i. p., oral, i. v.; 50 mg/kg, 200 mg/kg) shows a considerable antisecretory and antiulcer activity on different experimental models in the rats and dogs[1]. Animal Model: female Sprague-Dawley rats and male beagle dogs[1] Dosage: 50 mg/kg (rats); 200 mg/kg or 50 mg/kg (dogs) Administration: i. p., single (rats); oral, single or i. v. (dogs) Result: Showed an apparent plasma half-life of about 2.5 h in rats and 1 h in dogs and rapidly metabolized yielding two metabolites and two conjugates.
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References |
[1]. G. M. Pacifici, et al. Pharmacokinetics and biotransformation, in rats and dogs, of trithiozine, a new antisecretory drug. , 1(3), 141–147. doi:10.1007/bf03189268.
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