Tritiozine

Modify Date: 2024-01-13 22:59:37

Tritiozine Structure
Tritiozine structure
Common Name Tritiozine
CAS Number 35619-65-9 Molecular Weight 297.37000
Density 1.211g/cm3 Boiling Point 420.8ºC at 760mmHg
Molecular Formula C14H19NO4S Melting Point 141-143°
MSDS N/A Flash Point 208.3ºC

 Use of Tritiozine


Trithiozine is an orally active antisecretory and antiulcer agent. Trithiozine can be used for the research of peptic ulcer disease and hypersecretory disorders[1].

 Names

Name morpholin-4-yl-(3,4,5-trimethoxyphenyl)methanethione
Synonym More Synonyms

 Tritiozine Biological Activity

Description Trithiozine is an orally active antisecretory and antiulcer agent. Trithiozine can be used for the research of peptic ulcer disease and hypersecretory disorders[1].
Related Catalog
In Vivo Trithiozine (T) (i. p., oral, i. v.; 50 mg/kg, 200 mg/kg) shows a considerable antisecretory and antiulcer activity on different experimental models in the rats and dogs[1]. Animal Model: female Sprague-Dawley rats and male beagle dogs[1] Dosage: 50 mg/kg (rats); 200 mg/kg or 50 mg/kg (dogs) Administration: i. p., single (rats); oral, single or i. v. (dogs) Result: Showed an apparent plasma half-life of about 2.5 h in rats and 1 h in dogs and rapidly metabolized yielding two metabolites and two conjugates.
References

[1]. G. M. Pacifici, et al. Pharmacokinetics and biotransformation, in rats and dogs, of trithiozine, a new antisecretory drug. , 1(3), 141–147. doi:10.1007/bf03189268.

 Chemical & Physical Properties

Density 1.211g/cm3
Boiling Point 420.8ºC at 760mmHg
Melting Point 141-143°
Molecular Formula C14H19NO4S
Molecular Weight 297.37000
Flash Point 208.3ºC
Exact Mass 297.10300
PSA 72.25000
LogP 1.65800
Index of Refraction 1.57

 Synonyms

EINECS 252-645-4
Tritiozine
Tresanil
Tritiozina [INN-Spanish]
Tritiozina [Italian]
ISF 2001
4-(3',4',5'-trimethoxyphenyl)-thioxomethylmorpholine
Trithiozine
4-(3,4,5-Trimethoxythiobenzoyl)morpholine
Tritiozinum [INN-Latin]
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