Total Synthesis of the Potent Mutagen (S)-3-(Dodeca-l,3,5,7,9-pentaenyloxy)propane- 1,2-diol ... K. C. Nicolaou,* Robert Zipkin, and David Tanner Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA ... A total synthesis of the mutagenic (S)-3-(dodeca-l,3,5,7,9-pentaenyloxy)propane-l,2-diol (1) from (R)-glycerol acetonide (Z), potassium glutaconate (6), and the diphenylphosphine oxide (1 1) is reported.
